Extended Data Fig. 4: Margin of resection. | Nature Medicine

Extended Data Fig. 4: Margin of resection.

From: Neoadjuvant talimogene laherparepvec plus surgery versus surgery alone for resectable stage IIIB–IVM1a melanoma: a randomized, open-label, phase 2 trial

Extended Data Fig. 4

n = number of patients with protocol-defined surgery in the analysis set. Histopathology tumor-free margin (R0) surgical resection is defined by pathologist as absence of ink on the tumor in the resected specimen. 80% exact CI for binary rate of each arm is calculated using the Clopper-Pearson method. An 80% exact CI for between-arm differences in binary rate is calculated using Wilson’s score method with continuity correction. R1 surgical resection is defined as complete resection with no grossly visible tumor left behind as defined by the surgeon. R2 surgical resection is defined as partial resection with grossly visible tumor left behind as defined by the surgeon. CI = confidence interval; T-VEC = talimogene laherparepvec.

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