Extended Data Fig. 7: Summary of Clinical Improvement in Measures of Mast Cell Burden (AdvSM Safety Population).
From: Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial
*n values indicate number of patients with neoplastic mast cell aggregates at baseline. †n values indicate number of patients with baseline serum tryptase assessment. ‡Images by CT or MRI centrally assessed by independent radiologist. §Based on central laboratory testing. AdvSM, advanced systemic mastocytosis; ASM, aggressive systemic mastocytosis; CR, complete remission; CT, computed tomography; MCL, mast cell leukemia; MRI, magnetic resonance imaging; PR, partial remission; SM-AHN, systemic mastocytosis with an associated hematologic neoplasm; VAF, variant allele fraction.
