Fig. 2: Clinicopathologic measures of response and change in patient-reported measures of symptom burden by AdvSM-SAF score. | Nature Medicine

Fig. 2: Clinicopathologic measures of response and change in patient-reported measures of symptom burden by AdvSM-SAF score.

From: Safety and efficacy of avapritinib in advanced systemic mastocytosis: the phase 1 EXPLORER trial

Fig. 2

a, BM mast cell burden. b, Serum tryptase level. c, Spleen volume. d, KIT D816V VAF in BM, assessed by central ddPCR assay. e, Change from baseline in systemic mastocytosis symptom burden, evaluated by AdvSM-SAF TSS. For the change in TSS by AdvSM-SAF, a two-sided paired t-test was performed for the change from baseline at C3 (P < 0.001), C7 (P = 0.022) and C11 (P = 0.002). BL, baseline; CR, complete remission; VAF, variant allele fraction. AdvSM-SAF, advanced systemic mastocytosis symptom assessment form; ASM, aggressive systemic mastocytosis; BM, bone marrow; C, cycle; CIs, confidence intervals; ddPCR, droplet digital polymerase chain reaction; MCL, mast cell leukemia; SM-AHN, systemic mastocytosis with an associated hematologic neoplasm; TSS, total symptom score.

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