Fig. 1: Predicted absolute risk of primary symptomatic COVID-19 as a function of immune markers measured at PB28 by generalized additive regression.
From: Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection
a–d, Predicted absolute risk of primary symptomatic COVID-19 as a function of anti-spike IgG measured at PB28 (52 cases, 1,155 noncases included in the analysis) (a), anti-RBD IgG measured at PB28 (52 cases, 1,155 noncases included in the analysis) (b), pseudovirus neutralization antibody titers at PB28 (47 cases, 828 noncases included in the analysis (c), and live-virus neutralization antibody titers PB28 (36 cases, 412 noncases included in the analysis) (d). Gray horizontal lines show the overall risk of primary symptomatic COVID-19 in the control group (MenACWY) and vaccine groups (ChAdOx1 nCoV-19). Blue dots show the absolute risk predicted from the model across the range of antibody values included in the analysis, adjusting for baseline exposure risk to SARS-CoV-2 infection. Green shaded areas show the CI around the predicted mean probability (green line).
