Extended Data Fig. 5: Protection against PCR-positives with reported symptoms.

Note: data restricted to those aged 18-64 years old and the B.1.617.2-dominant period; lthc=self-reporting a long term health condition. All estimates (Vaccine effectiveness = 100% * (1-odds ratio)) were obtained from a generalised linear model with a logit link comparing to the reference category of ‘Not vaccinated, not previously positive and ≥21 days before vaccination’ and using clustered robust standard errors. The error bars represent 95% CIs. See Fig. 2 for effects on all PCR-positive episodes. See Table 3 for estimates of overall decline over time. See Supplementary Table 6 for estimates of VE within subgroups 14 days after second vaccination (intercept on panels below).