Extended Data Fig. 1: Kaplan-Meier estimate of time to first subsequent chemotherapy or death.

Treatment effects were compared using the stratified log-rank test; HRs and corresponding 95% CIs were estimated using the Cox proportional hazards model stratified by the presence of visceral metastasis (yes vs no) and menopausal status (postmenopausal vs premenopausal or perimenopausal). The P value is one-sided with no adjustment for multiplicity. HR = hazard ratio; NR = not reached.