Extended Data Fig. 8: Expression of BCMA in healthy donors of the Allen Brain Atlas and presence of CAR-T cells in CSF of patient. | Nature Medicine

Extended Data Fig. 8: Expression of BCMA in healthy donors of the Allen Brain Atlas and presence of CAR-T cells in CSF of patient.

From: Neurocognitive and hypokinetic movement disorder with features of parkinsonism after BCMA-targeting CAR-T cell therapy

Extended Data Fig. 8

(a) Microarray data on top illustrates the expression of TNFRSF17 (BCMA) in the caudate nucleus of 5 healthy brain donors. The bottom shows that regions of TNFRSF17 (BCMA) expression coincides with DRD1 (dopamine receptor D1) expression, a protein know to be highly specific for the caudate nucleus. Image credit: Allen Institute: © 2010 Allen Institute for Brain Science. Allen Human Brain Atlas; available from: human.brain-map.org. (b) Schematic representation showing the log2 intensity of TNFRSF17 (BCMA) RNA expression in a single patient from the Allen Brain Atlas. Image credit: Allen Institute: © 2010 Allen Institute for Brain Science. Allen Human Brain Atlas; available from: human.brain-map.org. (c) Quantitative representation of the Allen Brain Atlas data with boxplots (median, Q1 and Q3 quartiles, whiskers up to 1.5 x IQR) showing normalized expression (z-score) across all six donors for different brain structures (N = 6, total of 3,702 probes across 27 brain regions). The p-values shown correspond to a two-sided Mann-Whitney U test of striatum versus any other region (**: p < 0.001, ***: p < 0.0001, n.s.: p ≥ 0.05).

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