Extended Data Fig. 3: MRI and Ioflupane single photon emission computed tomography imaging after the onset of neurotoxicity. | Nature Medicine

Extended Data Fig. 3: MRI and Ioflupane single photon emission computed tomography imaging after the onset of neurotoxicity.

From: Neurocognitive and hypokinetic movement disorder with features of parkinsonism after BCMA-targeting CAR-T cell therapy

Extended Data Fig. 3

(a) MRI axial FLAIR (left) and T2 (right) images at the level of the deep brain nuclei (top) and the cerebral cortex (top), conducted at day 101 after CAR-T infusion. Images demonstrate small punctuate hyperintensities present on imaging prior to CAR-T therapy and putatively due to pre-existing microvascular damage. (b) Ioflupane (123-I) scan images, conducted at day 155 after CAR-T infusion, show normal uptake at the level of the basal ganglia.

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