Extended Data Fig. 4: Quantitative analysis of FDG-PET/CT images confirms decreased metabolism in caudate nucleus after CAR-T cell therapy. | Nature Medicine

Extended Data Fig. 4: Quantitative analysis of FDG-PET/CT images confirms decreased metabolism in caudate nucleus after CAR-T cell therapy.

From: Neurocognitive and hypokinetic movement disorder with features of parkinsonism after BCMA-targeting CAR-T cell therapy

Extended Data Fig. 4

(a) FDG-PET axial splash images pre (top) and post (bottom) CAR-T infusion. Shown is a spectral scale with high metabolism/perfusion in red, to low metabolism/perfusion in dark blue. (b) Quantitative analysis showing normalized Z-score for all available regions of the brain before (blue) and after (red) CAR-T infusion. The caudate is highlighted. The normalized score was calculated using MIMneuro, comparing the image with a library of 43 FDG neurologic controls (41-80 years old).

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