Extended Data Fig. 2: Characterization of the fetal enteroendocrine cell types.
From: Insulin is expressed by enteroendocrine cells during human fetal development
a, MA plot showing differentially expressed genes between fetal and neonatal enteroendocrine cells stratified by cell type. Genes in red have q-values below 0.05 and expression above 1e-4. INS, the most up-regulated gene in fetal K/L cells, is highlighted with a blue box. b, Spearman correlation distances between adult beta cells and the fetal endocrine cell types. Each dot represents a distance obtained from one of 100 bootstrap iterations, in which cells were sampled with replacement from the complete dataset. Distances from beta cells are significantly smaller for FIKL cells compared to all other enteroendocrine cell types (two-sided Wilcoxon rank-sum p = 1e-31 for the differences between FIKL cells and K/L INS- cells, the second closest enteroendocrine cell population). White circles are medians, gray boxes mark the 25–75 percentiles, gray lines extend from 1.5 times the interquartile range (IQR) above the 75 percentile to 1.5 times the IQR below the 25 percentile and truncated at the minimal or maximal measured values. c, RGS16 expression (log10 of the sum-normalized UMI counts).
