Extended Data Fig. 2: Forest plot of known biomarkers in urothelial carcinoma, renal cell carcinoma and prostate cancer.

Biomarkers shown among urothelial carcinoma (IMvigor210), renal cell carcinoma (IMmotion150), and prostate cancer (IMbassador250) for PFS. DDR, DNA damage response; PD-L1, programmed death- ligand 1; PFS, progression-free survival; Teff, effector T cell, TMB, tumor mutational burden. Med refers to median PFS in months. HRs and CIs were calculated using Cox proportional hazards regression model, and P values were calculated using unstratified log-rank test without adjustment for multiplicity.