Extended Data Fig. 1: Dose related increases in IL-15 in plasma.
Plasma levels of IL-15 obtained just prior to the first dose and then at several time-points over the subsequent 24 hours and at Day 4 are plotted for each dose. We plotted the 3 participants at each dose that completed all 3 doses. We noted that 2 individuals at the 1 mcg/kg dose (A) had high baseline levels of IL-15 whereas all 6 individuals at the 3 and 6 mcg/kg dose had low baseline levels and the expected increase with each subsequent injection.
