Fig. 2: Oral AB-2004 treatment reduces levels of several bacterial metabolites.
a–f, Metabolite levels in urine from BL (orange), EOT (blue) and FV (gray) time points from all participants, normalized to creatinine (µg metabolite per mmol creatinine) on log2 scale. Exact adjusted P values: 4EPS, 0.03; pCG, 0.002, 0.0003; pCS, <0.0001, <0.0001; 3IS, <0.0001, 0.0003; HPAA, 0.002; HPHPA, 0.0095; and HHA, 0.005, 0.02. Chemical structures are shown above associated data panels. Urine from one participant could not be obtained due to incontinence. Data analysis was conducted on the completers group (n = 26, with two missing data points in the FV time point because two participants missed assessment due to parental illness). Analysis is exploratory and post hoc in nature, shown as mean and 95% confidence interval analyzed with a linear mixed-effects model with Geisser–Greenhouse correction, multiple comparisons and false discovery rate correction across all metabolites (nominal P values: *Padj ≤ 0.05; **Padj ≤ 0.01; ***Padj ≤ 0.001; ****Padj ≤ 0.0001). creat., creatinine.
