Fig. 5: Metabolome and microbiome features altered uniquely in IHD and its subtypes.
From: Microbiome and metabolome features of the cardiometabolic disease spectrum
Circle plot shows gut microbial species and serum metabolites that were categorized as being specific to IHD or to its subtypes—ACS, CIHD and HF due to CIHD as per our categorization scheme shown in Fig. 3 and Extended Data Fig. 4. Each layer shows effect sizes (Cliff’s delta) for individual features that were either enriched or depleted in cases (IHD or its subtypes) versus HCs (see also Supplementary Table 17 for all features listed as being specific to IHD and its subtypes). Only features exhibiting absolute effect sizes greater than 0.1 for HC versus IHD are displayed. *The metabolite was not validated by an internal standard but confirmed with great confidence according to information from Metabolon (Methods) who performed the analysis. **An internal standard for the metabolite was not available but was confirmed with reasonable confidence according to information from Metabolon (Methods) who performed the analysis.
