Extended Data Fig. 6: Metagenomic sequencing identifies distinct taxa associated with various immune-related adverse events in PD-1-treated melanoma patients in Pittsburgh early cohort. | Nature Medicine

Extended Data Fig. 6: Metagenomic sequencing identifies distinct taxa associated with various immune-related adverse events in PD-1-treated melanoma patients in Pittsburgh early cohort.

From: Intestinal microbiota signatures of clinical response and immune-related adverse events in melanoma patients treated with anti-PD-1

Extended Data Fig. 6

Heatmap depicts metagenomic compositional differences between patients with a given immune-related adverse event (irAE) as compared to patients with other irAEs using scaled fold differences (high – red; low – blue) in abundances of specific bacteria. Values in individual cells represent unadjusted p-values calculated using two-tailed Mann-Whitney U test, with p-values <0.1 displayed within cells. Bar plot to left of heatmap indicates extent of association between corresponding taxa and progression-free survival probability [scaled hazard ratio (HR)], with Storey q-values <0.1 displayed within cells (from Supplementary Tables 4 and 5).

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