Fig. 3: Infection-neutralization capacity for SARS-CoV-2 variants of concern after breakthrough infection with Delta and Omicron in vaccinated individuals.
a, Serum IC50 values for infection-neutralization capacity normalized to 107 viral RNA copies of SARS-CoV-2 VoCs in 47 naive individuals (42 for Omicron) 2 weeks after vacc. 2 (dark blue), 59 naive individuals (light blue) and 36 convalescents 2 weeks after vacc. 3, as well as 16 and 15 vaccinated individu*als on average 7 d after PCR-confirmed breakthrough infections with Delta (green) and Omicron (purple), respectively; naive individuals 2 weeks after vacc. 2 versus naive individuals and convalescents 2 weeks after vacc. 3 ****P < 0.0001 for all variants, versus Delta breakthrough infection for EU1 ***P = 0.0007, Alpha ****P < 0.0001, Beta ***P = 0.0010, Gamma ***P = 0.0007, Delta ***P = 0.0006 and Omicron ***P = 0.0002, and versus Omicron breakthrough for EU1 *P = 0.0251, Alpha ***P = 0.0003, Beta **P = 0.0024, Gamma **P = 0.0016, Delta **P = 0.0022 and Omicron ****P < 0.0001. b, IgG-type anti-spike antibody avidities in 44 naive participants 2 weeks after vacc. 2 (dark brown), 19 naive (light blue) and 18 convalescent participants 2 weeks after vaccination 3, as well as 13 and 13 vaccinated individuals on average 7 d after PCR-confirmed breakthrough infections with Delta (green) and Omicron (purple), respectively; ****P < 0.0001. c, IgG-type anti-spike antibody avidity in vaccinated individuals on average 7 d (n = 13), 2 weeks (n = 14), 3 weeks (n = 10) and 4 weeks (n = 11) after PCR-confirmed breakthrough infections with Delta. Data are shown as boxplots with median, bounds between upper and lower quartiles, and whiskers between the 10th and 90th percentiles. Differences between groups were analyzed for their statistical significance using the Kruskal–Wallis test with Dunn’s multiple-testing correction. Connecting lines indicate statistically significant differences between groups. Absence of connecting lines or asterisks indicates absence of significance. w1, 7 d after infection; w2, 2 weeks after respective vaccination/infection; w3, 3 weeks after infection; w4, 4 weeks after infection.
