Extended Data Fig. 6: Longitudinal comparison of the ratios between infection neutralization capacities against VoCs and anti-SARS-CoV-2 antibodies in naive individuals and convalescents after BNT162b2 vaccination.

Ratios between serum IC₅₀ values for infection-neutralization capacity against VoCs and antibody titers to the S1 domain of SARS-CoV-2 spike antigen shown as box plots with median, bounds between upper and lower quartiles, and whiskers between the 10^th and 90^th percentiles in SARS-CoV-2 convalescents (regardless of whether or not they received vaccination #2, orange) and naive participants (blue). a-e, 263 sera from 62 convalescents, and 295 sera from 73 naives; (f) 258 sera from 62 convalescents, and 278 sera from 73 naives. a, convalescent w2 after vaccination (vacc.) #3 vs. m4 vacc. #2 ^**P=0.0091, and vs. m7 vacc #2 ^*P=0.0401, w2 vacc. #2 vs. m7 vacc. #2 ^**P=0.0012, m4 vacc. #2 vs. pre-vaccination (pre) ^**P=0.0015, and vs. w2 vacc. #2 ^**P=0.0093, naive m4 vacc. #2 vs. w2 vacc. #3 ^***P=0.0002. b, convalescent w2 vacc. #2 vs. m4 vacc. #2 ^**P=0.0025, w2 vacc. #2 vs. m7 vacc. #2 ^**P=0.0018, w2 vacc. #3 vs. m4 vacc. #2 ^***P=0.0003, and vs. m7 vacc. #2 ^***P=0.0002. c, convalescent m4 vacc. #2 vs. pre ^**P=0.0030, and vs. w2 vacc. #2 ^***P=0.0003, m7 vacc. #2 vs. pre ^**P=0.0074, and vs. w2 vacc. #2 ^***P=0.0008, w2 vacc. #3 vs. pre ^*P=0.0250, vs. w2 vacc. #1 ^***P=0.0005, and vs. w2 vacc. #2 ^**P=0.0023. d, convalescent pre vs. w2 vacc. #1 ^**P=0.0082, m4 vacc. #2 vs. w2 vacc. #1 ^***P=0.0001, and vs. w2 vacc. #2 ^**P=0.0064, m7 vacc. #2 vs. w2 vacc. #2 ^**P=0.0017, w2 vacc. #3 vs. pre ^***P=0.0006, and vs. m4 vacc. #2 ^*P=0.0408, naive m7 vacc. #2 vs. w2 vacc. #3 ^**P=0.0034. e, convalescent m4 vacc. #2 vs. pre ^**P=0.0030, and vs. w2 vacc. #2 ^***P=0.0003, m7 vacc. #2 vs. pre ^**P=0.0052, and vs. w2 vacc. #2 ^***P=0.0005, pre vs. w2 vacc. #3 ^***P=0.0005, naive w2 vacc. #3 vs. m4 vacc. #2 ^**P=0.0027, and vs. m7 vacc. #2 ^**P=0.0032. f, convalescent pre vs. m4 vacc. #2 ^*P=0.0340, naive w2 vacc. #2 vs. m4 vacc. #2 ^**P=0.0077, m4 vacc. #2 vs. m7 vacc. #2 ^**P=0.0011, a-f, ^****P<0.0001. Connecting lines indicate statistically significant differences between groups. Absence of connecting lines or asterisks indicates absence of significance. Differences between time points were analysed for their statistical significance using the Kruskal-Wallis test with Dunn’s multiple testing correction. The data depicted in panels (e, f) are also shown in Fig. 2 and were added to this extended data figure to enhance comparability. Abbreviations, pre: prior to first vaccination; #1 – first vaccination; #2 – second vaccination; #3 – third vaccination; w2 – two weeks after respective vaccination; m4 – 4 months after vaccination; m7 – 7 months after vaccination.

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