Fig. 5: Posterior predicted mean days (95% CrI) from the second vaccination/infection to the threshold level associated with 67% protection.

The threshold level is 107 BAU ml−1 for ChAdOx1, 94 BAU ml−1 for BNT162b2 and 33 BAU ml−1 for unvaccinated. a, In participants without prior infection and vaccinated with ChAdOX1 (n = 92,584). b, In participants without prior infection and vaccinated with BNT162b2 (n = 51,034). c, In unvaccinated participants who had natural infection (n = 3,271). d, Predicted probability of seroconverting in unvaccinated participants who had natural infection, based on a previous model on seroconversion16. Estimates were separated by age, sex, dosing interval, long-term health condition (LTHC) and vaccine type for vaccinated people and by age, sex and LTHC for unvaccinated people. y axis is truncated at 800 days for visualization. For ChAdOx1, 20-year-old group is not plotted because the vast majority of those receiving ChAdOx1 were 40 years of age or older. a–c are conditional on participants having antibody response/seroconverting (see the ‘Vaccine non-responders’ section for ChAdOx1 and BNT162b2 and discussion in a previous publication16 for unvaccinated individuals).