Fig. 2: Blood biomarker analysis in pCOVID-19 and MIS-C.
a, Comparison of serum biomarker levels in children with MIS-C Early (n = 48) (within 7 days since admission) and MIS-C Late (more than 7 days after admission, n = 60), pCOVID-19 (n = 57) within 7 days from symptom onset and pHCs (n = 53). b, Comparison of type I IFN score in paired MIS-C Early and MIS-C Late (n = 11), pHC (n = 12) and pCOVID-19 (n = 15) with elevated (pCOVID-19hi, n = 6) and lower (pCOVID-19low, n = 9) IFN-α2a levels. c, Comparison of NF-κB score and type II IFN score in paired MIS-C Early and MIS-C Late (n = 11), pCOVID-19 (n = 15) and pHC (n = 12). d, Random forest classification comparing pCOVID-19 within 7 days from symptom onset (n = 57) to pHC (n = 53). e, Random forest classification comparing MIS-C Early (n = 48) to pHC (n = 53). f, Random forest classification comparing MIS-C Early (n = 48) to pCOVID-19 within 7 days from symptom onset (n = 57). g, Serum spike protein levels in MIS-C (n = 21), pCOVID-19 (n = 9) and pHC (n = 16). Maxima of box plots in a, b, c and g represent median values, and bars represent IQR. Statistical analysis in a–c and g was performed by Kruskal–Wallis test with adjustment for multiple comparisons. P values are marked as follows: *P < 0.05, **P < 0.01, ***P < 0.001 and ****P < 0.0001.
