Extended Data Fig. 7: Detection of hFVIII protein in human liver and co-localization with organelle-specific markers for lysosomes (LAMP2) and endoplasmic reticulum (GRP78). | Nature Medicine

Extended Data Fig. 7: Detection of hFVIII protein in human liver and co-localization with organelle-specific markers for lysosomes (LAMP2) and endoplasmic reticulum (GRP78).

From: Interindividual variability in transgene mRNA and protein production following adeno-associated virus gene therapy for hemophilia A

Extended Data Fig. 7

LAMP2, GRP78 and hFVIII protein co-staining of hepatocytes from study participant biopsies and one normal liver. Images shown are representative of one section per study participant; the entire biopsy section was reviewed to evaluate hFVIII, LAMP2 and GRP78 co-localization. Images were captured at 2048 × 2048 pixels and output at 300 ppi. LAMP2, lysosome-associated membrane glycoprotein 2; GRP78, glucose-regulated protein 78.

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