Fig. 3: Differential gene expression of selected genes potentially mediating low hFVIII-SQ RNA levels in participant 15. | Nature Medicine

Fig. 3: Differential gene expression of selected genes potentially mediating low hFVIII-SQ RNA levels in participant 15.

From: Interindividual variability in transgene mRNA and protein production following adeno-associated virus gene therapy for hemophilia A

Fig. 3

a, Relationship between PHF5A expression and normalized hFVIII-SQ RNA levels in liver biopsy samples of participants (P) who received 4 × 1013 vg per kg body weight (blue) or 6 × 1013 vg per kg body weight (green) valoctocogene roxaparvovec. b, HDAC9 gene expression in participants who received 4 × 1013 vg per kg body weight (blue) or 6 × 1013 vg per kg body weight (green) valoctocogene roxaparvovec. TPM, transcripts per million.

Source data

Back to article page