Extended Data Fig. 7: Correlation between standardized, adjusted PRS and odds of disease in MGBB participants of unknown or other reported race. | Nature Medicine

Extended Data Fig. 7: Correlation between standardized, adjusted PRS and odds of disease in MGBB participants of unknown or other reported race.

From: Development of a clinical polygenic risk score assay and reporting workflow

Extended Data Fig. 7

Plots show log(odds) of each of six diseases versus quantile (n = 50 for T2D, n = 10 for all other disease) of standardized population structure-adjusted PRS (PRSstd-adj) among up to 3,113 MGBB participants of unknown or other reported race. Results not reported for CRCa due to 0 cases in at least one quantile (n = 10). The correlation coefficient, r, is shown in each panel. Abbreviations: AFib, atrial fibrillation; BrCa, breast cancer; CAD, coronary artery disease; CRCa, colorectal cancer; MGBB, Mass General Brigham Biobank; OR, odds ratio; PrCa, prostate cancer; PRS, polygenic risk score; T2D, type 2 diabetes.

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