Table 1 Prevalence and disease associations of high-risk PRS for six diseases in MGBB overall and by reported race

From: Development of a clinical polygenic risk score assay and reporting workflow

Disease

High risk (%)a

OR overall

OR white

OR Black

OR Asian

OR Other/Unknown

  

OR (95% CI)b (n/n, n/n)c

OR (95% CI)b (n/n, n/n)c

OR (95% CI)b (n/n, n/n)c

OR (95% CI)b (n/n, n/n)c

OR (95% CI)b (n/n, n/n)c

BrCa

8.6

2.38

(2.07–2.73)

(286/1,400, 1,427/16,606)

2.39

(2.07–2.76)

(270/1,156, 1,318/13,495)

2.24

(0.97–5.15)

(7/73, 43/1004)

0.51

(0.07–3.9)

(1/33, 24/405)

2.35

(1.08–5.1)

(8/138, 42/1,702)

CRCa

5.4

2.37

(1.74–3.24)

(46/1,913, 346/34,117)

2.29

(1.65–3.19)

(41/1,646, 312/28,717)

4.11

(1.17–14.48)

(3/83, 15/1706)

0

(0–NaN)

(0/35, 7/744)

3.30

(0.73–14.88)

(2/149, 12/2,950)

PrCa

13.1

2.22

(1.98–2.48)

(498/1,698, 1,693/12,813)

2.31

(2.05–2.59)

(468/1,448, 1,544/11,017)

1.39

(0.74–2.59)

(14/71, 74/521)

2.58

(0.5–13.28)

(2/36, 6/279)

1.41

(0.78–2.58)

(14/143, 69/996)

AFib

8.3

2.37

(2.12–2.64)

(450/2,589, 2,282/31,101)

2.40

(2.14–2.69)

(422/2,179, 2,101/26,014)

1.47

(0.72–3.01)

(9/137, 71/1590)

2.00

(0.57–7.03)

(3/62, 17/704)

2.28

(1.32–3.94)

(16/211, 93/2,793)

CAD

9.8

1.86

(1.69–2.05)

(562/3,018, 2,991/29,851)

1.91

(1.73–2.12)

(503/2,459, 2,680/25,074)

1.41

(0.86–2.29)

(21/177, 125/1484)

3.96

(1.79–8.76)

(9/51, 31/695)

1.47

(0.97–2.22)

(29/331, 155/2,598)

T2D

8.4

1.75

(1.57–1.95)

(439/2,612, 2,924/30,447)

1.93

(1.71–2.17)

(367/2,284, 2,159/25,906)

1.21

(0.7–2.09)

(18/57, 358/1374)

1.07

(0.37–3.08)

(4/49, 52/681)

1.58

(1.14–2.19)

(50/222, 355/2,486)

  1. High-risk PRS, defined here as a standardized, adjusted PRS (PRSstd-adj) associated with OR > 2 for disease in the original publication. aProportion of MGBB participants exceeding the literature-derived OR > 2 threshold for each disease. bObserved OR (95% CI) in up to 36,423 MGBB participants in the overall cohort and by race reported in the MGBB. c(ncaseshigh-risk PRS/ncontrolshigh-risk PRS, ncaseswithout high-risk PRS/ncontrolswithout high-risk PRS). NaN, not a number.
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