Table 1 Immune responses measured in CoviCompare
From: A comparison of Sars-Cov-2 vaccine platforms: the CoviCompare project
Humoral immune responses | Spike serology, isotypes and subclasses |
Neutralization and pseudoneutralization assays using SARS-CoV-2 (Wuhan strain and variants of concern) | |
Immunoprofiling/LIPS SARS-CoV-2 (S S1 S2 RBD) | |
Serology for other coronaviruses | |
T cell-mediated responses | FluoroSpot T cell assays |
T cell-specific phenotyping (subgroup of FluoroSpot) | |
Memory B cell responses | Memory B cell ELISpot |
B cell receptor repertoire | |
Innate immune responses | Transcriptomic analysis (3′ RNA sequencing) |
Cytokines (Simoa) and anti-cytokines (ELISA) | |
Innate and B cell phenotyping | |
Mucosal immune response testing | IgA, IgM and IgG salivary anti-S and anti-RBD |
IgA and IgG salivary anti-S ultrasensitive | |
ADCC/neutralization |
