Fig. 1: Sensitivity of Omicron BA.1 and BA.2 to therapeutic mAbs.
a, Mutational landscape of Omicron BA.1 and BA.2 spike proteins. Domains of the protein are color-coded: NTD, N-Terminal Domain; RBD, Receptor-Binding Domain; RBM, Receptor-Binding Motif; SD1, subdomain 1; SD2, subdomain 2, S1/S2, region proximal to the furin cleavage site. Mutations in the amino acid sequence are indicated in comparison to the ancestral Wuhan-Hu-1 sequence (GenBank: NC_045512). Light orange boxes indicate mutations shared by BA.1 and BA.2, and orange boxes indicate mutations unique to BA.1 and BA.2. b, Neutralization curves of mAbs. Dose–response analysis of the neutralization by the indicated antibodies and by Evusheld, a combination of cilgavimab and tixagevimab. Data are mean ± s.d. of 2–8 independent experiments. The IC50 values for each antibody are presented in Table 1. NTD, N-terminal domain.
