Extended Data Fig. 3: (a) Somatic point substitution and (b) indel spectra with corresponding mutational signatures for each of the twins.
From: In utero origin of myelofibrosis presenting in adult monozygotic twins
We identified 514 and 705 somatic single-nucleotide variants (SNVs), 240 and 44 somatic indels, and 5 structural variants unique to twin A and twin B, respectively. Analysis of the somatic point substitution signatures revealed shared signatures with near identical contributions in twin A and B. Indel signatures differed markedly between the twins; ID1 and ID12 accounted for respectively 57% and 43% of indels in twin A, while all indels in twin B were attributable to ID9.
