Fig. 3: Correlations between T cell subsets in CT041 and clinical activity in patients with GC.

a,b, Forest plots showing Cox regression analysis of the effect of T cell subsets on PFS and OS. a, Univariate analysis between PFS and infused subset cell numbers—product characteristics. b, Univariate analysis between OS and infused subset cell numbers—product characteristics. Dots and bars show the hazard ratios and 95% CIs for each T cell subset, respectively; P values were calculated using the Cox regression model, for n = 28 patients with GC. Logistic regression analyses were performed to determine the correlation among the frequencies of CD3⁺CD4⁺CD8⁻ (Th) cells (c), CD3⁺CD4⁻CD8⁺ (CTLs) (d), CD45RA⁺/CCR7⁺ (naive T) cells (e), CD45RA⁻/CCR7⁺ (central memory T) cells (f), CD45RA⁻/CCR7⁻(effector memory T) cells (g) or CD45RA⁺/CCR7⁻(terminally differentiated effector T) cells (h) in CT041 product to probability of response. CT041 was evaluated before infusion. Shaded bands show the 95% CIs of predicted probability, and lines present the predicted probability of response from logistic regression analyses with nominal P values (that is, without adjustment for multiplicity), for n = 28 patients with GC.