Two new studies provide robust epidemiological evidence and a mechanistic link, with potential implications for strategies that target Epstein–Barr virus.
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References
Banwell, B. et al. Lancet Neurol. 10, 436–445 (2011).
Bar-Or, A. et al. Trends Mol. Med. 26, 296–310 (2020).
Nourbakhsh, B. et al. Ann. Neurol. 89, 1234–1239 (2021).
Goodin, D. S. Med Res Arch 9, 29 (2021).
Veroni, C. & Aloisi, F. Front. Immunol. 12, 665718 (2021).
Bjornevik, K. et al. Science 375, 296–301 (2022).
Lanz, T. V. et al. Nature 603, 321–327 (2022).
Levin, L. I., Munger, K. L., O’Reilly, E. J., Falk, K. I. & Ascherio, A. Ann. Neurol. 67, 824–830 (2010).
Soldan, S. S. & Lieberman, P. M. Drug Discov. Today Dis. Models 32, 35–52 (2020).
Cencioni, M. T., Mattoscio, M., Magliozzi, R., Bar-Or, A. & Muraro, P. A. Nat. Rev. Neurol. 17, 399–414 (2021).
Lassmann, H., Niedobitek, G., Aloisi, F. & Middeldorp, J. M. Brain 134, 2772–2786 (2011).
Messick, T. E. et al. Sci. Transl. Med. 11, 5612 (2019).
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A.B.-O. has participated as a speaker in meetings sponsored by and has received consulting fees from Accure, Atara Biotherapeutics, Biogen, BMS/Celgene/Receptos, GlaxoSmithKline, Gossamer, Janssen/Actelion, Medimmune, Merck/EMD Serono, Novartis, Roche/Genentech and Sanofi-Genzyme, and has received grant support to the University of Pennsylvania from Biogen Idec, Roche/Genentech, Merck/EMD Serono and Novartis.
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Bar-Or, A., Banwell, B., Berger, J.R. et al. Guilty by association: Epstein–Barr virus in multiple sclerosis. Nat Med 28, 904–906 (2022). https://doi.org/10.1038/s41591-022-01823-1
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DOI: https://doi.org/10.1038/s41591-022-01823-1
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