Fig. 4: Refining neuroanatomical treatment targets for addiction.
From: Brain lesions disrupting addiction map to a common human brain circuit
a–c, Neuroanatomical targets for treatment of addiction based on previous work included the insula (green, a), anterior cingulate (green, b) and frontal cortex (electric field models of the H4 and H7 TMS coils shown in blue-green, c). Voxels whose connectivity profile best matched our lesion-based addiction remission network included the left operculum/insula (red-yellow, a), paracingulate gyrus (red-yellow, b) and medial fronto-polar cortex (red-yellow, c). Therapeutic targets identified using LNM overlapped previous targets (right, a–c) but also provided testable hypotheses for how these targets might be refined or improved. Additional images for the electric field models of the H4 and H7 TMS coils (c) are shown in Supplementary Fig. 12.
