Table 4 Associations between maternal and child PRS for IBD, UC, Crohn’s at P-value threshold 0.05, and standardized autism factor mean score in the children of the ALSPAC birth cohort

From: Parental inflammatory bowel disease and autism in children

Exposure

β (95% CIs)

P

Maternal IBD PRS

0.02 (−0.004, 0.04)

0.1

Maternal UC PRS

0.02 (0.003, 0.05)

0.03

Maternal Crohn’s PRS

0.03 (0.01, 0.05)

0.004

Child’s IBD PRS

0.003 (−0.02, 0.02)

0.79

Child’s UC PRS

0.001 (−0.02, 0.02)

0.89

Child’s Crohn’s PRS

0.007 (−0.01, 0.03)

0.49

  1. N = 7,348 mother-child pairs for analyses involving mothers’ PRSs. N = 7,503 children for analyses involving children’s PRS. Beta coefficients, 95% CIs, and P values calculated by linear regression of the PRS for IBD, UC, or Crohn’s on the standardized autism factor mean score in the children, adjusted for child’s sex and the first ten principal components of the ALSPAC genotype data. Higher standardized autism factor mean scores (mean = 0, s.d. = 1) reflect more autism-related difficulties. There were no multiple-test corrections made.
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