Extended Data Fig. 2: Risk score distributions in eMERGE-III (N = 22,453) and UKBB (N = 77,584) validation datasets.
From: Genome-wide polygenic score to predict chronic kidney disease across ancestries
Risk score distributions in eMERGE-III (N = 22,453) and UKBB (N = 77,584) validation datasets: (a) the distribution of raw polygenic score without APOL1 in UKBB by ancestry; (b) the distribution of ancestry-adjusted polygenic score (method 1: mean-adjusted) in UKBB by ancestry; (c) the distribution of ancestry-adjusted polygenic score (method 2: mean and variance-adjusted) in UKBB by ancestry. Panels (d), (e) and (f) show the same analyses for the eMERGE-III dataset, respectively.
