Extended Data Fig. 2: Scatterplot of the observed VE and genetic distance on the non-S proteins of SARS-CoV-2.

The same analysis under the null hypothesis to explore the association of VE with genetic distance was performed on the structural proteins containing envelope (E), membrane (M) and nucleocapsid (N); ORF1ab; accessory proteins containing ORF3a, ORF6, ORF7a, ORF7b, ORF8 and ORF10 proteins. No significant relationship with VE was observed.