Table 2 Recurrent mutations observed along the SARS-CoV-2 phylogeny

From: Drivers of adaptive evolution during chronic SARS-CoV-2 infections

Protein

Mutation

Clade success

Times observed in chronic infections (n)

ORF1a

T3255I

+

1

ORF1a

S3675-,G3677-,F3678-

+

0

S

L18F

+

0a

S

T95I

+

1

S

L452R

+

0

S

N501Y

+

2

S

P681R

+

0

N

P199L

+

0

ORF1a

L3606F

–

1

S

H69-,V70-

–

1

S

Y144-

–

7b

S

E484K

–

10c

S

P681H

–

0

N

S194L

–

0

N

T205I

–

0

N

M234I

–

0

  1. High clade success or low clade success is reported based on measurements of clade logistic growth, with + or – representing higher or lower than average growth, respectively30. The last column marks the number of patients in the set of chronic infections herein where a substitution was observed.
  2. aTwo deletion events were observed at this locus.
  3. bAn additional two deletion events were observed at loci 141–143.
  4. cIn three additional patients, E484Q was observed.
Back to article page