Extended Data Fig. 6: Deterministic Visualisation of Mutational Trajectories in the LBC36.
From: Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects
a. Deterministic trajectories (see SI methods Appendix B) with maximum a posteriori (MAP) fitness and wild-type stem cells and fitted time of mutation (left) and posterior distribution of fitness associated to each clonal structure (right) inferred for all mutations selected by LiFT in each participant of the LBC1936 cohort. 90% confidence intervals associated with binomial sampling noise are shown for each data point. Note that VAF is displayed on a logarithmic scale to highlight relative differences and the initial exponential growth of clones. To use a logarithmic axis, data points with zero observations have been replaced by VAF = 0.001, or a factor of 10 below our observation threshold. Also note that a small random horizontal jitter has been added to data points to avoid overlapping of confidence intervals.
