Extended Data Fig. 7: Sc-RNA seq analysis of edited and unedited patient PBMCs. | Nature Medicine

Extended Data Fig. 7: Sc-RNA seq analysis of edited and unedited patient PBMCs.

From: CRISPR–Cas9-mediated gene editing of the BCL11A enhancer for pediatric β0/β0 transfusion-dependent β-thalassemia

Extended Data Fig. 7

a, Marker gene expression for subtypes from PBMCs. b, UMAP plots representing 13 color-coded cell clusters identified in single-cell transcriptomes of PBMCs from 2 heathy donors, 1 patient sample before treatment and 3 patient samples at different time points after treatment. c, Violin plots showing BCL11A expression (log transformed) for B cell cluster from each sample. Wilcox two-tailed test, with each p-value, is indicated above the comparison group.

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