Extended Data Fig. 2: RP-HPLC analysis of globin chains in treated patients. | Nature Medicine

Extended Data Fig. 2: RP-HPLC analysis of globin chains in treated patients.

From: CRISPR–Cas9-mediated gene editing of the BCL11A enhancer for pediatric β0/β0 transfusion-dependent β-thalassemia

Extended Data Fig. 2

RP-HPLC analysis of globin chains in healthy donor and two patients (at Month 9, 15 and 18). RP-HPLC chromatograms are reported together with the non–α: α ratio (in brackets). The various globin chains detected were labeled on top and their respective peak shape ranges were marked with a gray background. Gamma globin chains were robustly induced in both patients. The expression of a common AγT chain variant was detected in samples derived from Patient 2. After treatment, the two patients had equal amounts of alpha and non-alpha chains in their blood after treatment as that of healthy donor.

Source data

Back to article page