Extended Data Fig. 3: Representative indel tables of two patients’ edited cells. | Nature Medicine

Extended Data Fig. 3: Representative indel tables of two patients’ edited cells.

From: CRISPR–Cas9-mediated gene editing of the BCL11A enhancer for pediatric β0/β0 transfusion-dependent β-thalassemia

Extended Data Fig. 3

Summary of most frequent indels by deep sequencing of the genome from input CD34+ cells, PBMCs Mo7 after transplantation, and PBMCs Mo15 after transplantation from study patients. The reference sequence at the top of the figure is part of the BCL11A enhancer DNase I hypersensitive site (DHS) + 58 functional core. Gata1 motif marked with green box, and the sgRNA targets the complementary strand of the gata1 motif sequence.

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