Extended Data Fig. 4: Representative indel tables of two patients’ engrafted cells. | Nature Medicine

Extended Data Fig. 4: Representative indel tables of two patients’ engrafted cells.

From: CRISPR–Cas9-mediated gene editing of the BCL11A enhancer for pediatric β0/β0 transfusion-dependent β-thalassemia

Extended Data Fig. 4

Summary of most frequent indels by deep sequencing result of T cells, B cells, NK cells, Monocytes and Neutrophils sorted from peripheral blood at Mo15 post transplantation from study patients. The reference sequence at the top of the figure is part of the BCL11A enhancer DNase I hypersensitive site (DHS) + 58 functional core. Gata1 motif marked with green box, and the sgRNA targets the complementary strand of the gata1 motif sequence.

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