Extended Data Fig. 4: Clinical and genomic determinants of response to NAT in LARC.

(a) Frequency of somatic alterations in rectal cancer driver genes for the patients used in our analyses of clinical outcomes, stratified by cohort. (b) Frequency of somatic alterations in oncogenic signaling pathways for the patients used in our analyses of clinical outcomes, stratified by cohort. (c) Left panel shows results from a multivariate analysis of associations between CR and a combination of clinicopathological and genomic features using a logistic regression model. The error bars indicate the 95% confidence interval. Right panel shows results from a multivariate analysis of associations between DFS and a combination of clinicopathological and genomic features using a Cox proportional hazards model. The results shown in this panel were obtained using patients treated with CRT-CNCT. (d) The left panel shows a multivariate analysis of associations between CR and a combination of clinicopathological and genomic features using a logistic regression model. The error bars indicate the 95% confidence interval. The right panel shows results from a multivariate analysis of associations between DFS and a combination of clinicopathological and genomic features using a Cox proportional hazards model. The results shown in this panel were obtained using patients treated with INCT-CRT.