Extended Data Fig. 8: Neuromas within the Virchow-Robin space. | Nature Medicine

Extended Data Fig. 8: Neuromas within the Virchow-Robin space.

From: Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial

Extended Data Fig. 8

In some cases, neuromas extended down into the Virchow-Robin space of the dorsal and ventral horns of the spinal cord, shown with (a – a”) H&E and (b) Nissl. Structures stained positive for (c) S100 and (d) Collagen IV, and (e) negative for GFAP. Structures stained positive for (f) nestin and (g) neurofilament (NF). (h) There was no observed staining for Ki67. (i) CD34 demonstrated normal appearing blood vessels within the structures. Scale bars: (a) 400 μm; (a’, d) 200 μm; (a”) 100 μm; (b, c, d’, e-i) are all the same 100 μm scale bar size shown in a”.

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