Table 2 Clinical outcomes according to ejection fraction category and randomized therapy
≤30% | >30 and ≤37% | >37 and ≤44% | >44 and ≤51% | >51 and ≤60% | >60% | Pooled cohort | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Placebo | Dapa | Placebo | Dapa | Placebo | Dapa | Placebo | Dapa | Placebo | Dapa | Placebo | Dapa | Placebo | Dapa | |
CV death | ||||||||||||||
n/N | 154/1,099 | 126/1,062 | 74/785 | 65/799 | 106/900 | 93/963 | 109/947 | 96/915 | 96/1,054 | 102/1,088 | 68/718 | 43/677 | 607/5,503 | 525/5,504 |
Rate per 100 patient years (95% CI) | 9.9 (8.5–11.6) | 8.4 (7.0–10.0) | 6.4 (5.1–8.1) | 5.6 (4.4–7.1) | 6.8 (5.6–8.2) | 5.4 (4.4–6.6) | 5.2 (4.3–6.3) | 4.7 (3.9–5.8) | 4.1 (3.3–4.9) | 4.2 (3.4–5.1) | 4.3 (3.4–5.4) | 2.8 (2.1–3.8) | 5.9 (5.4–6.4) | 5.1 (4.6–5.5) |
HR (95% CI) | 0.85 (0.67–1.07) | 0.86 (0.61–1.20) | 0.81 (0.61–1.07) | 0.91 (0.69–1.20) | 1.02 (0.77–1.34) | 0.68 (0.47–1.00) | 0.86 (0.76–0.97) | |||||||
All-cause death | ||||||||||||||
n/N | 172/1,099 | 145/1,062 | 94/785 | 78/799 | 147/900 | 137/963 | 169/947 | 153/915 | 159/1,054 | 169/1,088 | 114/718 | 91/677 | 855/5,503 | 773/5,504 |
Rate per 100 patient years (95% CI) | 11.1 (9.5–12.9) | 9.6 (8.2–11.3) | 8.1 (6.6–10.0) | 6.7 (5.3–8.3) | 9.4 (8.0–11.0) | 7.9 (6.7–9.4) | 8.0 (6.9–9.3) | 7.5 (6.4–8.8) | 6.7 (5.7–7.8) | 6.9 (5.9–8.0) | 7.2 (6.0–8.6) | 6.0 (4.9–7.4) | 8.3 (7.7–8.8) | 7.4 (6.9–8.0) |
HR (95% CI) | 0.87 (0.70–1.09) | 0.81 (0.60–1.09) | 0.86 (0.68–1.08) | 0.94 (0.75–1.17) | 1.02 (0.82–1.27) | 0.86 (0.65–1.13) | 0.90 (0.82–0.99) | |||||||
Total HF hospitalizations | ||||||||||||||
n/N | 274/1,099 | 179/1,062 | 128/785 | 111/799 | 171/900 | 119/963 | 219/947 | 179/915 | 250/1,054 | 165/1,088 | 134/718 | 95/677 | 1176/5,503 | 848/5,504 |
Rate per 100 patient years (95% CI) | 17.8 (15.8–20.0) | 11.9 (10.3–13.8) | 11.2 (9.4–13.3) | 9.5 (7.9–11.5) | 10.9 (9.4–12.7) | 6.9 (5.8–8.38) | 10.5 (9.2–12.0) | 8.8 (7.6–10.2) | 10.6 (9.4–12.0) | 6.8 (5.8–7.9) | 8.5 (7.1–10.0) | 6.3 (5.2–7.7) | 11.4 (10.8–12.1) | 8.2 (7.7–8.8) |
RR (95% CI) | 0.66 (0.54–0.80) | 0.84 (0.64–1.09) | 0.62 (0.48–0.79) | 0.84 (0.68–1.03) | 0.63 (0.51–0.77) | 0.77 (0.59–1.02) | 0.71 (0.65–0.78) | |||||||
HF hospitalization | ||||||||||||||
n/N | 179/1,099 | 118/1,062 | 93/785 | 74/799 | 102/900 | 88/963 | 131/947 | 107/915 | 150/1,054 | 107/1,088 | 81/718 | 66/677 | 736/5,503 | 560/5,504 |
Rate per 100 patient years (95% CI) | 12.4 (10.7–14.4) | 8.2 (6.9–9.8) | 8.6 (7.0–10.5) | 6.6 (5.3–8.3) | 6.9 (5.7–8.4) | 5.4 (4.4–6.6) | 6.7 (5.7–8.0) | 5.6 (4.6–6.7) | 6.9 (5.8–8.1) | 4.6 (3.8–5.6) | 5.4 (4.4–6.8) | 4.6 (3.6–5.9) | 7.7 (7.1–8.2) | 5.7 (5.2–6.2) |
HR (95% CI) | 0.66 (0.52–0.83) | 0.76 (0.56–1.03) | 0.78 (0.59–1.04) | 0.83 (0.64–1.07) | 0.66 (0.51–0.84) | 0.88 (0.64–1.22) | 0.74 (0.66–0.82) | |||||||
CV death, MI or stroke | ||||||||||||||
n/N | 176/1,099 | 153/1,062 | 99/785 | 88/799 | 133/900 | 125/963 | 150/947 | 130/915 | 139/1,054 | 153/1,088 | 91/718 | 66/677 | 788/5,503 | 715/5,504 |
Rate per 100 patient years (95% CI) | 11.6 (10.0–13.4) | 10.3 (8.8–12.1) | 8.8 (7.2–10.7) | 7.7 (6.2–9.5) | 8.7 (7.3–10.3) | 7.4 (6.2–8.9) | 7.3 (6.3–8.6) | 6.6 (5.5–7.8) | 6.0 (5.1–7.1) | 6.4 (5.5–7.5) | 5.8 (4.7–7.2) | 4.5 (3.5–5.7) | 7.8 (7.3–8.4) | 7.1 (6.6–7.6) |
HR (95% CI) | 0.90 (0.72–1.11) | 0.86 (0.65–1.15) | 0.87 (0.68–1.11) | 0.89 (0.70–1.13) | 1.07 (0.85–1.34) | 0.77 (0.56–1.06) | 0.90 (0.81–1.00) | |||||||
CV death or HF hospitalization | ||||||||||||||
n/N | 271/1,099 | 203/1,062 | 141/785 | 117/799 | 183/900 | 153/963 | 195/947 | 173/915 | 209/1,054 | 175/1,088 | 129/718 | 92/677 | 1128/5,503 | 913/5,504 |
Rate per 100 patient years (95% CI) | 18.8 (16.7–21.2) | 14.1 (12.3–16.2) | 13.0 (11.0–15.3) | 10.4 (8.7–12.5) | 12.5 (10.8–14.4) | 9.3 (8.0–10.9) | 10.0 (8.7–11.5) | 9.0 (7.8–10.4) | 9.6 (8.4–11.0) | 7.5 (6.5–8.7) | 8.7 (7.3–10.3) | 6.4 (5.2–7.9) | 11.7 (11.1–12.4) | 9.2 (8.7–9.9) |
HR (95% CI) | 0.75 (0.63–0.90) | 0.79 (0.62–1.01) | 0.75 (0.61–0.93) | 0.90 (0.73–1.10) | 0.77 (0.63–0.95) | 0.77 (0.59–1.00) | 0.78 (0.72–0.86) | |||||||
