Fig. 5: Analysis of the metabolomic state informs on metabolite profiles associated with disease risk.

a, Heatmap showing the importance of metabolites in regard to the estimated metabolomic states, represented by absolute global SHAP value estimates per endpoint for the 75 globally most important metabolites. Endpoints are sorted by the discriminative performance of the metabolomic state (left to right; Fig. 3a). b, Global metabolite attributions for T2D; individual attributions are aggregated by percentiles and each dot indicates one percentile. The more distant a dot from the circular baseline, the stronger the absolute attribution for that percentile. Deviations toward the center and periphery represent negative and positive contributions, respectively, to the metabolomic state. Colors indicate the metabolite’s mean plasma value. c, Global metabolite attributions for all-cause dementia. IDL, intermediate-density lipoprotein.