Fig. 5: Causal relationships between microbiomes and plasma metabolites as assessed by MR analysis. | Nature Medicine

Fig. 5: Causal relationships between microbiomes and plasma metabolites as assessed by MR analysis.

From: Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

Fig. 5

a, Analysis of the association between adenosylcobalamin biosynthesis pathway abundance and 5-hydroxytryptophol levels. b, Glycogen biosynthesis pathway abundance versus 5-sulfo-1,3-benzenedicarboxylic acid levels. c, E. rectale abundance versus hydrogen sulfite levels. d, Veillonella parvula abundance versus 2,3-dehydrosilybin levels. In the top panels of a–d, the x axis shows the SNP exposure effect, and the y axis shows the SNP outcome effect and each dot represents a SNP. Error bars represent the s.e. of each effect size. The bottom panels of a–d, show the MR effect size (center dot) and 95% CI for the baseline (blue) and follow-up (green) datasets of the LLD1 cohort, estimated with the IVW MR approach (two sided) (n = 927 biologically independent samples at baseline and n = 311 biologically independent samples at follow-up).

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