Extended Data Fig. 7: Dosage plot for homoarginine and chronic renal failure variant associations.
From: Rare and common genetic determinants of metabolic individuality and their effects on human health
Dosage plot showing, for each variant in the homoarginine metabolite score, the estimated risk of chronic renal failure (log(OR per allele) versus the estimated effect on homoarginine levels (per 1 s.d. change per allele). Each dot represents the point estimates from the respective linear/logistic regression models using the genetic variant as exposure and either the metabolite or disease status as outcome (n = 334577, n cases=16389; for metabolite, n = 14295 cases for chronic renal failure). Lines indicate 95%-confidence intervals.
