Fig. 3: Variance explained, MAF versus effect size and functional annotation.
From: Rare and common genetic determinants of metabolic individuality and their effects on human health
a, The percentage of phenotypic variance of each metabolite explained by conditionally independent associations. The variance explained is partitioned into that explained by variants within each MAF bin, and indicated by color: rare (purple), low-frequency (pink) and common (orange). Three groups of metabolites are defined, with rare, low-frequency or common variants explaining the greatest percentage of phenotypic variance of the metabolite. The five metabolites with the greatest percentage of phenotypic variance explained by rare, low-frequency or common variants are listed, with the total percentage of variance explained by all variants in that MAF bin shown in parentheses. b, The phenotypic variance of each metabolite explained by variants within each MAF bin as a percentage of the variance explained by all conditionally independent associations. c, MAF versus association effect size for conditionally independent associations, with variants colored by functional annotation class as indicated in d. d, A bar plot of the frequency of variants in each functional class.
