Extended Data Fig. 6: ⁸⁹ZED88082A tumor uptake in relation to response.

a, Relationship between pretreatment ⁸⁹ZED88082A uptake and best overall response; red dots show geometric mean SUV_max per patient. Violin plot areas show actual distribution of SUV_max at the metastasis level per category, white dots and values below the violin plot show geometric means, black vertical lines show 95% CIs of geometric mean SUV_max (PD: 149 lesions in 19 patients; SD: 6 lesions in two patients, PR: 41 lesions in eight patients; CR: 36 lesions in four patients). b, Relationship between pretreatment ⁸⁹ZED88082A uptake in patients with progressive disease and those that did not progress. c, Relationship between pretreatment ⁸⁹ZED88082A uptake in patients with progressive disease and those with PR or CR, excluding SD. a-c, Two-sided nominal P-values were derived from linear mixed models taking clustering within patients into account, using a Wald test under restricted maximum likelihood for three or higher-level factors or a likelihood ratio test under maximum likelihood for two-level factors and for the trend test. d-e, Changes in tumor lesion SUV_max between the pre- and on-treatment PET scans. Patients are grouped per best overall response (PD, or no-PD). Violin plots show actual distribution of individual lesions. Baseline (BL) to response scan 1 (RS1, on-treatment) trajectories of individual lesions are shown with grey lines, projected at 30 days, when PET scan was regularly performed; red lines and dots (geometric means) present per-patient aggregated data; white dots are the overall geometric means with black 95% CI bars. Two-sided nominal P-values were derived from linear mixed models taking clustering within patients and lesions into account, using a Wald test under restricted maximum likelihood. d, Compared to pre-treatment, patients with SD, PR, or CR show a lowered uptake on the on-treatment PET scan than those with PD (P_interaction = 0.018). e, Same change in SUV_max, projected at 5 cm³ tumour volume to adjust for volume changes (P_interaction = 0.71).