Extended Data Fig. 7: PET image examples of uptake in non-malignant sites.
From: Whole-body CD8+ T cell visualization before and during cancer immunotherapy: a phase 1/2 trial

Axial (a-d, i), coronal (e, f), and sagittal (g, h) views of 89ZED88082A PET scans with low dose CT. a, High uptake in urinary bladder diverticulum with urolithiasis and accompanying inflammation. b, Uptake in an aortic atherosclerotic plaque, also detectable on non-attenuated corrected images (data not shown). c, Uptake post-surgery in a patient after inguinal lymph node dissection with a seroma. d, Bilateral uptake in subcutaneous inflammation reaction on heparin injections. e, Hashimoto’s thyroiditis with high uptake before treatment and f, Increased uptake during treatment experiencing a flare-up. g-h, Two patients who received radiotherapy to the spine; arrows indicate the border of the radiation field; the insert shows the radiation field. The irradiated bone marrow in the spine, shows less uptake than non-irradiated bone marrow. g, Patient who received 5×4 Gy to the spine for painful bone metastases 3 months before 89ZED88082A PET scan. h, Patient who received 25×1.8 Gy on para-aortal lymph nodes alongside the spine 12 months before the 89ZED88082A PET scan. i, Uptake of tracer in normal appendix on PET (right), with corresponding diagnostic CT (left).