Extended Data Fig. 7: Evidence of target inhibition in AML blasts.
a-e, Effect of IACS-010759 on levels of (a) NAD+, (b) nicotinamide, (c) tryptophan, (d) glutamine, or (e) alanine in AML blasts from Patients 16, 17, and 19 from AML Cohort 4. Y-axis shows metabolite levels relative to pre-dose levels. N = 4, n = 7, or n = 5 biologically independent samples for Patients 16, 17, or 19 respectively. Differences from pre-trial levels analyzed by a simple linear regression. g-f, Effect of IACS-010759 exposure on NMP, NDP, and NTP levels in AML blasts from (f) Patient 19 and (g) Patient 16 from AML Cohort 4. Y-axis shows nucleotide levels respective to pre-dose levels. N = 4 biologically independent samples. Differences from pre-trial levels analyzed by a simple linear regression.
