Extended Data Fig. 5: Correlations between plasma IACS-010759 concentration and baseline oxygen consumption rate (OCR) from AML blasts.
Baseline OCR has been normalized to cell number. Closed circles are predose and open circles indicate post dose values. Blue indicates pre-dose (C1D1). Red indicates after one week of QD dosing (C1D7 - Cohorts 3, 4; C1D14 - Cohorts 1, 2). Black closed circles are other timepoints collected during cycle 1. Correlations analyzed by a two-tailed Pearson’s correlation coefficient test; p < 0.05. Each symbol represents the mean +/− 95% confidence interval derived from technical replicates. a, n = 3 at C1D8(6), C1D10; n = 5 at C1D1, C1D1(6) C1D8, and C1D14; n = 6 at all other times. b, n = 5 at C1D8, C1D8(6), C1D22(6), C1D28, C1D28(6); n = 6 at all other times. c, n = 6. d, n = 2 at C1D9, C1D14(6), C1D25(6), C1D28, C1D28(6); n = 3 at C1D8, C1D8(6), C1D14, C1D17, C1D17(6); n = 4 at C1D2, C1D10; n = 5 at C1D1, C1D1(6). e, n = 5 at C1D10; n = 6 at all other times. f, n = 4 at C1D8(6); n = 6 at all other times. g, n = 4 at C1D1(4); n = 5 at C1D1; n = 6 at all other times. h, n = 6. i, n = 2 at C1D7(4); n = 3 at C1D7, C1D15, C1D15(4), n = 6 at C1D1, C1D1(4). j–k, n = 6. l, n = 3 at C1D1, C1D1(4); n = 4 C1D7, C1D7(4); n = 6 at all other times.
