Extended Data Fig. 5: Serial echocardiograms following dual AAV9 ABE editing of Myh6h403/+ mice.
From: Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice
a–f, Left ventricular anterior wall thickness at diastole (a) left ventricular posterior wall thickness at diastole (b), left ventricular internal diameter at diastole (c) and systole (d), ejection fraction (e), and fractional shortening (f), of Myh6WT mice, Myh6h403/+ mice, or ABE-treated Myh6h403/+ mice from 8–16 weeks of age. n = 5 male mice for each group. Exact P values can be found in Table 1. Data are mean ± s.e.m. *P < 0.05, **P < 0.01 by Student’s unpaired two-sided t-test for Myh6WT mice compared to Myh6h403/+ mice (black) and ABE-treated Myh6h403/+ mice compared to Myh6h403/+ mice (green). g, Representative M-mode images for Myh6WT mice, Myh6h403/+ mice, and ABE-treated Myh6h403/+ mice at 16 weeks of age.
